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LifeLines has been very successful in establishing its position as a scientific study and biobank. LifeLines participates in, a.o.:

1. the P3G consortium (www.p3g.org).
This Public Population Project in Genomics (P³G) is a non-for-profit international consortium promoting collaboration between researchers in the field of population genomics. Since its foundation, LifeLines has been an active member of P3G. This means that many of the LifeLines questionnaires have been harmonized and standardized on the basis of P3G best practices.

 

2. BBMRI-Europe.
This Biobanking and Biomolecular Resources Research Infrastructure is a pan-European and internationally broadly accessible research infrastructure and a network of existing and de novo biobanks and biomolecular resources. The infrastructure includes samples from patients and healthy persons, representing different European populations (with links to epidemiological and health care information), molecular genomic resources and biocomputational tools to optimally exploit this resource for global biomedical research. As a follow-up project, the scientific BioShaRE project (funded in KP7 with 12 mill. Euro) aims to develop and apply methods and tools that will provide a foundation for an ambitious program of harmonisation and standardisation in European biobanks and major biomedical studies. LifeLines is one of the participating cohorts in BioShaRE-EU, which is led by prof. Ronald Stolk (head of Epidemiology of the UMCG) and Paul Burton (geneticist, Leicester).

 

3. BBMRI-NL.
This Dutch collaboration of population-based and disease-oriented Biobanks in The Netherlands comprises an array of quality-assessed biobanks with greatly improved accessibility, enriched in a targeted, expert-driven manner to an up-to-date informational content, for maximum utility to the public and private biomedical field, and for optimal integration with larger international activities.
Within BBMRI-NL, LifeLines is actively participating in several collaborations, amongst others in projects devoited to biomarkers, gene expression, harmonization and standardization, and nutrition.

 

4. Ti-Pharma.
Top Institute Pharma (TI Pharma) is a public-private partnership in which scientific and business worlds work together on groundbreaking, multidisciplinary research aimed at improving the development of socially valuable medicines. This research precedes the stage in which companies develop individual medicines commercially. Our institute acts as an essential link in combining the knowledge present in science and industry. Collaboration within our research projects provides unique opportunities to strengthen the scientific foundation of pharmaceutical research in the Netherlands.
Within TIPharma, the Mondriaan project -in which LifeLines is participating- aims to develop “A grid to integrate and to enrich existing and new health data platforms in order to fuel pharmaceutical research in The Netherlands and to play an internationally competitive role in drug intelligence and innovation”. Existing databases in the Netherlands will be combined into a common framework; to analyze and update/optimize existing collection of data and acquire new access to health care data; to find optimal technological solutions for access, protection and storage of health care data either at a single or multiple locations; to design a structure to make best scientific use of the data both for academic and industrial partners. New methods and techniques will be established to utilize data from various sources such as GP electronic charts, hospital discharge data, pharmacies, etc.

 

5. Ti-Food and Nutrition.
Top Institute (TI) Food and Nutrition is a unique public/private partnership that generates scientific breakthroughs in food and nutrition. This results in the development of innovative products and technologies that respond to consumer demands for safe, tasty and healthy foods. Activities have started to join TiFN with specific projects related to nutrition and multifactorial diseases.

 

6. NCHA, National Consortium on Healthy Ageing.
The Netherlands Consortium for Healthy Ageing (NCHA) originally was an alliance between the Leiden University Medical Centre, the Erasmus Medical Centre, Unilever, Philips Healthcare, Galápagos and McRoberts. In its second phase, several other parties joined the consortium, and the UMCG is one of them. Objective of NCHA is the develop a thorough understanding of the (healthy) ageing process and of age-related diseases. It studies interventions that may be applied to protect and preserve health: new ways for prevention, diagnosis, prognosis, treatment and self-management regarding age-related disease.
LifeLines has joined NCHA (http://www.healthy-ageing.nl/) as a full member, with a research focus on (Epi)genomics in age-related diseases in the LifeLines Cohort Study.

 

Until November 3, 2011, almost 68,000 subjects have been included in the study. The 60,000th participant was screened in the beginning of September 2011. Recruitment rate at present is between 700 and 800 subjects per week. At present, all 12 anticipated research sites have opened their doors, and are actively screening participants. Because of the amount of plasma, serum, DNA and urine samples handled by the laboratory each day, a state-of-the-art sample management system including several robots was built to manage all blood and urine samples.

The table shows the percentage of participants who reported a specific health problem or disease. Of course many more disease are registered, this just gives you some insight in specific prevalences. We expect that the number of co-morbidities will rise significantly during the upcoming months now that we are screening many subjects in the age group of 65 years and above.

Table 1. Self-reported health-related problems by LifeLines participants
COPD, chronic obstructive pulmonary disease, 5.3 %
Hay fever or certain kind of allergy, 21.9 %
Has suffered from cancer, 4.1 %
Known to have diabetes, 2.1 %
Complaints of arthrosis, 6.4 %
Colitis ulcerosa or Crohn's disease, 0.9 %
Osteoporosis, 1.3 %
Psoriasis, 2.6 %

 

BioShare-EU: Biobank Standardisation and Harmonisation for Research Excellence in the European Union.

BioSHaRE-EU has assembled a consortium of leading international researchers from all domains of biobanking science. The project will work to develop and apply methods and tools that will provide a foundation for an ambitious program of harmonisation and standardisation in European biobanks and major biomedical studies. This will facilitate the full participation of European bioscience in the next phase of international aetiological research that will demand access to studies that have three complementary characteristics:
(1) participants must be comprehensively assessed not only for genotype, but also for phenotype, with some assessment necessarily being longitudinal;
(2) measurement quality (accuracy and precision) must be high;
(3) for many of the scientific questions that will need to be addressed, no single study will provide adequate numbers of subjects that are measured/assessed sufficiently well – biobanks must therefore be harmonised and standardised so that studies can pool biobank data in valid and effective ways.

The BioSHaRE-EU project will address all the key issues relevant to achieving the necessary biobank standardisation and harmonisation, by focusing upon several inter-related areas of work.

Collaborating centers and organisations:
1 University Medical Center Groningen, The Netherlands
2 University of Leicester, United Kingdom
3 Norwegian Institute of Public Healt, Norway
4 University of Helsinki, Finland
5 Helmholtz Zentrum München, Germany
6 Norwegian University of Science and Technolog, Norway
7 Karolinska Institutet, Sweden
8 Institut National de la Sante et de la Recherche Médicale, France
9 University of Manchester, United Kingdom
10 Legal Pathway, The Netherlands
11 McGill University, Canada
12 Medical University of Graz, Austria
13 Public Population Project in Genomics, Canada
14 Ontario Institute For Cancer Research, Canada
15 University of Oxford, United Kingdom
16 Imperial College, United Kingdom

BioShare-EU is lead by prof. Stolk, UMCG, and prof. Burton, Leicester, and has a 12 million Euro budget.

What are the overall aims and objectives of the LifeLines Cohort Study?

Overall aim of the LifeLines Study is to unravel the interaction between genetic and environmental factors in the development of multifactorial diseases, their concurrent development in individuals and their complications as a complex trait.

Primary objectives are:
a. Which are the disease overriding risk factors which predict the development of a multifactorial disease during lifetime?
b. How are these universal risk factors modified, or what determines the effect of a universal risk factor in an individual?
Specific research questions will focus on risk factors and modifiers (genetic, environmental and combined or complex factors) for single and multiple diseases. In addition to co-morbidity, LifeLines focuses on co-determinants. The primary endpoints include measures of ageing, metabolic and endocrine diseases, cardiovascular and renal diseases, pulmonary and musculoskeletal diseases, and psychopathology.

Secondary aims include the assessment of the prevalence and incidence of multifactorial diseases, their risk factors and their treatment in individuals as well as in families. The burden of disease for the society will be quantified in terms of care needed, and total costs of care.

The LifeLines database contains questionnaire data, physical measurements and biological samples from different health examinations. More details on their content can be found in the LifeLines Protocols. Collaboration is encouraged as it helps to maximize the scientific value of the wealth of epidemiologic data made possible by the participation of more than 165,000 individuals in the LifeLines Cohort Study.

 

jigsawMultifactorial diseases are by definition the result of multiple risk factors that are both genetically and environmentally determined. Multifactorial diseases may have more in common than generally recognized, since some risk factors are associated with multiple diseases, suggesting an individual susceptibility for specific risk factors.

Since different diseases share identical risk factors, it is clear that an exclusive focus on associations between single risk factors and single outcomes will not unravel the unresolved issues of aetiology and individual prognosis of multifactorial diseases. Instead, research has to focus on the underlying mechanisms why individuals with similar (established) risk factors develop different diseases, i.e. the modification of the universal risk factors for multiple disorders.

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