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LifeLines has established a number of activities which are important for its development as a world-player in biobanking over the next three years. They comprise disease-overriding research themes, which will stimulate mutual collaboration between researchers from different fields of medicine and from different universities.
The following themes have been decided upon
1. Interaction and connection of database systems between LifeLines and GP's
2. Health Technology and Innovation,
3. 'Social context'
4. Nutrition and lifestyle
5. Systems biology and genetic epidemiology
LifeLines has decided to appoint theme coordinators who have the responsibility to build and facilitate such interdisciplinary collaborations and formation of national and international research networks. Applying for research grants and other funding is an important part of these activities. This will enable formation of these networks, continuation of data collection and enrichment of the LifeLines cohort with new data and measurements during the upcoming years.
The general theme of LifeLines is multimorbidity, i.e. research into why many people develop more than one chronic disease during their life. In all themes we follow the approach how genetic and environmental factors play together in promoting disease, and how the mechanistically (DNA polymorphisms) and pathophysiologically (mechanistic pathways) reinforce each other.
LifeLines contains two technical themes:
1. Interaction and connection of database systems between LifeLines, GP's and others.
In this theme there is extensive collaboration with GP organisations, amongst others NIVEL, the Registratie Netwerk Groningen, and SFK, Stichting Farmaceutische Kengetallen. This collaboration will vastly enrich and expand LifeLines to incorporate all types of information on its participants' health career.
2. Health Technology and Innovation.
In this theme, we focus on new methods and techniques for better evaluation, assessment and monitoring of disease processes, and vice-versa to stimulate implementation of LifeLines scientific results in practice for better and personalized diagnostics and prevention. Important techniques are bio-imaging, functional MRI, lab-on-a-chip, but also sensor- and nano-technology.
In addition, there are three more scientifically oriented themes:
3. Social context.
This theme addresses important issues of social and psychological determinants and aspects of health and disease. How do social and societal developments influence our health, the way we assess health and try to maintain it, but also how chronic diseases affect an individual, his coping behaviour, health behaviour, and the development of psychological co-morbidity. Special focus is placed on the interrelationship between chronic diseases and aspects of societal participation and work, amongst others through 'Healthy Ageing at Work' projects, and outreach to health-promoting projects on a regional level.
4. Nutrition and Lifestyle.
The theme on Nutrition and lifestyle stimulates research on the topics how food, food constituents and physical activity (or the lack of it) contribute to the development of chronic diseases. This does not only comprise research on intake of calories, but also on the specific aspects and effects of particular food constituents on all aspects of health and physical functioning. Because of the important effects that nutrients can have on gut function and the intestinal bacterial flora, research will specifically aim to assess the interplay between the 'bacterioma of the gut' and our health. This theme is well connected with the theme 'Gut health' of TiFN (Top Institute Food and Nutrition).
5. Systems biology and genetic epidemiology.
Now that the first wave of whole-genome analysis studies has been published, this field of research is slowly evolving to a number of new areas. At the one hand there are activities to find genes with low frequency, but high impact on disease development by deep-sequencing, on the other hand there are other complementary techniques like epigenetics and genomic imprinting, and finally research on biomarkers is essential to predict the development or course of diseases (for example proteomics) or to better evaluate metabolic changes in chronic diseases (metabolomics). The theme “systems biology and genetic epidemiology” will further develop these techniques that can help in finding new leads for development of drugs or other modes of intervention or prevention, or of functional foods or food constituents to improve bodily functions like cognition or memory.
The following persons are presently acting as theme coordinators:
* Social context: prof. dr. Ute Bültmann, Department of Health Sciences, Section of Social Medicine, Work & Health, University Medical Center Groningen and University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
* Nutrition and Lifestyle: prof. dr. Edith Feskens, Division of Human Nutrition, Wageningen University Research Center, Wageningen Netherlands.
* Systems biology and genetic epidemiology: prof. dr. H. Snieder, Dept. of Genetic Epidemiology, University Medical Center Groningen and University of Groningen, P.O. Box 30001, 9700 RB Groningen.